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Successful reversal of neutropenia in Felty's syndrome with recombinant granulocyte colony stimulating factor
Author(s) -
Choi ManFung Vincent,
Mant Michael J.,
Turner A. Robert,
Akabutu John J.,
Aaron Stephen L.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04805.x
Subject(s) - felty's syndrome , granulocyte colony stimulating factor , neutropenia , medicine , recombinant dna , granulocyte , regimen , sweet's syndrome , surgery , immunology , gastroenterology , chemotherapy , biology , biochemistry , gene
Summary. We report two patients with Felty's syndrome and chronic skin ulcers treated successfully with recombinant granulocyte colony stimulating factor (GCSF). In both cases granulocytes returned to the normal range within days of starting treatment, and their cutaneous ulcers improved. In one patient granulocytes were maintained at normal levels with a regimen of GCSF 3 μg/kg twice weekly for 14 months.