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Immunodeficiency and IL‐6 production by peripheral blood monocytes in multicentric Castleman's disease
Author(s) -
Ishiyama Taijiro,
Nakamura Shinji,
Akimoto Yoshihisa,
Koike Michiaki,
Tomoyasu Shigeru,
Tsuruoka Nobuyoshi,
Murata Yaeko,
Sato Tadatsugu,
Wakabayashi Yoshihisa,
Chiba Shyozo
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04777.x
Subject(s) - medicine , peripheral blood , disease , castleman disease , peripheral , immunology , pathology
Summary. To study the pathogenesis of multicentric Castleman's disease (MCD), IL‐6 producing cells and immune function were investigated in four MCD patients. The expression of IL‐6 mRNA in one MCD lymph node was analysed by in situ hybridization. IL‐6 mRNA expressing cells were scattered in the interfollicular areas and did not resemble plasma cells. Spontaneous IL‐6 production was detected in the culture supernatants of peripheral blood mononuclear cells (PBMNC) from four patients. The IL‐6 producing cells among the PBMNC were found to be monocytes by both in situ hybridization and immunohistochemistry. We evaluated immune function in four MCD patients. These studies show: (1) a negative PPD skin test in 3/4 patients. (2) decreased IL‐2 production in 3/4 patients, (3) decreased T cell colony formation in 3/4 patients, (4) decreased NK activity and NK cell number in 2/4 patients, (5) increased soluble IL‐2 receptor in 4/4 patients, and (6) decreased CD4/CD8 ratio in 3/4 patients. These results show that MCD resembles, in several ways, acquired immunodeficiency syndrome (AIDS).