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Parvovirus B19‐associated haemophagocytic syndrome with prominent neutrophilia
Author(s) -
Tsuda Hiroyuki,
Maeda Yosuke,
Nakagawa Kazumi,
Nakayama Masafumi,
Nishimura Hachiro,
Ishihara Akira,
Miyayama Haruhiko
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04756.x
Subject(s) - neutrophilia , parvovirus , neutropenia , immunology , granulocyte colony stimulating factor , medicine , tumor necrosis factor alpha , granulocyte , myocarditis , virus , toxicity , chemotherapy
Summary We describe a patient with both haemophagocytic syndrome and acute myocarditis probably associated with parvovirus B19 infection. The patient had a marked neutrophilia instead of neutropenia more usually observed in virus‐associated haemophagocytic syndrome (VAHS). Endogenous serum concentrations of macrophage colony‐stimulating factor (M‐CSF), granulocyte colony‐stimulating factor (G‐CSF), and tumour necrosis factor‐α (TNF‐α) were higher than normal, suggesting that these cytokines may be involved in the genesis of the observed syndrome.