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Virus‐associated haemophagocytic syndrome: further evidence for a T‐cell mediated disorder
Author(s) -
Watson Henry G.,
Goulden Nicholas J.,
Manson Lynn M.,
McDermid George,
Gray James A.,
Parker Alistair C.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb03282.x
Subject(s) - virus , medicine , immunology , disease , cytokine , virology
A 16‐year‐old youth with life‐threatening virus‐associated haemophagocytic syndrome (VAHS) responded remarkably to treatment with cyclosporin A during two periods of active disease, the second of which was due to non‐compliance with treatment. Our clinical observations support the hypothesis that VAHS is cytokine driven as a result of an aberrant T‐cell response to infection.