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An improved DNA‐based identification of fetuses at risk for HPA‐1a (Pl A1 ) neonatal alloimmune thrombocytopenia
Author(s) -
Clemenceau Sylvie,
Perichon Bruno,
Elion Jacques,
Kaplan Cecile,
Krishnamoorthy Rajagopal
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb03277.x
Subject(s) - neonatal alloimmune thrombocytopenia , fetus , typing , medicine , identification (biology) , immunology , pregnancy , pediatrics , biology , genetics , botany
A simple and reliable procedure, based on DNA amplification and Hpa II mapping, is proposed for the identification of fetuses at risk for HPA‐1a (Pl A1 ) neonatal alloimmune thrombocytopenia which could cause life‐threatening haemorrhage, even in early fetal life. This typing procedure for HPA‐1 alleles should help in deciding, very early, the therapeutic management of the fetuses at risk.