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Localized, late‐onset, high‐grade lymphoma following bone marrow transplantation: response to combination chemotherapy
Author(s) -
O'Riordan J. M.,
Molloy K.,
O'Briain D. S.,
Corbally N.,
Devaney D.,
McShane D.,
Considine N.,
McCann S. R.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb03272.x
Subject(s) - lymphoma , medicine , chemotherapy , chop , bone marrow , transplantation , lymphoproliferative disorders , non hodgkin's lymphoma , oncology , pathology
Non‐Hodgkin's lymphoma is the commonest secondary cancer following bone marrow transplantation (BMT). We report the case of a 42‐year‐old man who developed a laryngeal high‐grade B‐cell lymphoma 5 years following a matched T depleted BMT for CML. Polymerase chain reaction (PCR) analysis using the microsatellite marker Cyp 19 demonstrated the donor origin of involved tissue. Epstein‐Barr virus (EBV) genomic sequences were identified by PCR. Although EBV related B‐cell lymphoproliferative disorders (BLPD) post BMT are difficult to treat, there was a complete remission in this patient following three courses of chemotherapy (CHOP) administered with G‐CSF. This case of late‐onset BLPD appears clinically distinct from the well‐defined, aggressive, early post‐transplant BLPD.