Premium
Use of granulocyte colony‐stimulating factor (G‐CSF) for mobilizing peripheral blood stem cells: risk of mobilizing clonal myeloma cells in patients with bone marrow infiltration
Author(s) -
Vora Ajay J.,
Toh Cheng Hoc,
Peel Janet,
Greaves Michael
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb03271.x
Subject(s) - stem cell , bone marrow , granulocyte colony stimulating factor , haematopoiesis , medicine , multiple myeloma , bone marrow stem cell , infiltration (hvac) , granulocyte , immunology , chemotherapy , biology , microbiology and biotechnology , physics , thermodynamics
Peripheral blood stem cells have been used for autologous reconstitution of haemopoiesis after high dose cytotoxic therapy and produce similar disease response rates as autologous bone marrow transplants. Peripheral blood stem cell transplants are an especially attractive option for patients in whom marrow harvest is not feasible due to bone marrow damage or infiltration. Recombinant growth factors mobilize adequate numbers of stem cells from the marrow but their effect on tumour cell circulation kinetics is not known. We report a patient with multiple myeloma and bone marrow infiltration in whom the use of G‐CSF for stem cell mobilization led to release of plasma cells into the peripheral circulation and contamination of the stem cell harvest.