Premium
B‐cell lymphoma of recipient origin 9 years after allogeneic bone marrow transplantation for T‐cell acute lymphoblastic leukaemia
Author(s) -
Trimble Malcolm S.,
Waye John S.,
Walker Irwin R.,
Brain Michael C.,
Leber Brian F.
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb08651.x
Subject(s) - lymphoma , medicine , lymphoblastic lymphoma , bone marrow , transplantation , malignancy , immunology , hematopoietic cell , haematopoiesis , acute lymphocytic leukemia , leukemia , cancer research , pathology , stem cell , t cell , lymphoblastic leukemia , biology , immune system , genetics
Summary. A 25‐year‐old woman developed an immuno‐blastic lymphoma 9 years after HLA‐identical allogeneic bone marrow transplantation for T‐cell acute lymphoblastic leukaemia in second remission. The B‐cell origin of the second malignancy was confirmed by gene rearrangement studies. Despite continued donor engraftment, two separate genotypic analyses identified the lymphoma to be of recipient origin. This is the longest latency of a post‐transplant recipient lymphoma yet reported and illustrates that recipient B‐cells may survive the transplant conditioning regimen and undergo malignant transformation in the presence of donor haemopoiesis.