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Danazol in autoimmune haemolytic anaemia
Author(s) -
Pig JeanMichel,
Poirson Emmanuelle,
Rochant Henri
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb08293.x
Subject(s) - danazol , prednisone , medicine , splenectomy , refractory (planetary science) , gastroenterology , immunology , spleen , endometriosis , biology , astrobiology
Ten adult patients with warm antibody haemolytic anaemia at initial presentation and seven other patients with either refractory AiHA (two patients) or who relapsed after an initial response to prednisone (five patients) were treated with both Danazol and prednisone. 80% of the first group, but also 60% of the second group displayed long‐lasting responses (mean follow up 21 months). Minimal side‐effects occurred. Finally, addition of Danazol at presentation in warm AIHA may decrease the duration of prednisone therapy and markedly reduce the necessity of second‐line splenectomy which is usually required in many patients.