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A unique case of t(15;17) acute promyelocytic leukaemia (M3) developing into acute myeloblastic leukaemia (M1) with t(7;21) at relapse
Author(s) -
Jubashi Tohru,
Nagai Kazuhiro,
Miyazaki Yasushi,
Nakamura Hideo,
Matsuo Tatsuki,
Kuriyama Kazutaka,
Tomonaga Masao
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb04709.x
Subject(s) - medicine , chromosomal abnormality , acute myeloblastic leukemia , myeloid leukaemia , phenotype , complete remission , oncology , leukemia , chemotherapy , biology , karyotype , gene , genetics , chromosome
Summary. This report describes a case of t(15;17) acute promyelcytic leukaemia (APL, FAB subtype M3) with dysgranulopoiesis at diagnosis in a patient who developed myelodysplasia (MDS) and then a second phenotype of t(7;21) acute myeloblastic leukaemia (AML, FAB subtype M1) at the time of relapse. To our knowledge, there is no report of a second phenotype of AML occurring after complete remission (CR) of APL. Furthermore, this is the first report of chromosomal abnormality t(7;21) in a case of AML. Several hypotheses for this unusual course of APL are discussed.