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Summarizing data on survival, relapse, and chronic graft‐versus‐host disease after bone marrow transplantation: motivation for and description of new methods
Author(s) -
Pepe Margaret Sullivan,
Longton Gary,
Pettinger Mary,
Mori Motomi,
Fisher Lloyd D.,
Storb Rainer
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb04697.x
Subject(s) - medicine , survival analysis , bone marrow transplant , disease , bone marrow , incidence (geometry) , graft versus host disease , bone marrow transplantation , randomized controlled trial , clinical trial , oncology , surgery , mathematics , geometry
Summary. Kaplan‐Meier curves are frequently used to summarize survival, relapse, and chronic graft‐versus‐host disease (GVHD) data in the bone marrow transplant setting. Some fundamental problems with the use of Kaplan‐Meier curves for the summary of relapse and GVHD are described. Alternatively, the use of simple probability and conditional probability curves for summarizing relapse incidence and transplant‐related mortality is illustrated with previously published data from a randomized clinical trial. Prevalence curves provide an appropriate alternative for the summary of a transient condition such as chronic GVHD. When combined with Kaplan‐Meier curves for survival and/or relapsefree survival, these methods provide a more accurate and comprehensive summary of the various marrow transplant outcomes. These methods of display are also applicable to other settings where more than one type of treatment failure can occur and where follow‐up time may be variable.