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Blood film features of sickle cell–haemoglobin C disease
Author(s) -
Bain Barbara J.
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb04679.x
Subject(s) - hemoglobinopathy , disease , cell , hemoglobin s , hemoglobin c , medicine , sickle cell anemia , red blood cell , hemoglobin , immunology , gastroenterology , biology , genetics
Summary. The blood films of patients with sickle cell‐haemoglobin C disease (SC) were compared with those of patients with related haemoglobinopathies in order to establish the most characteristic features. The blood films from SC patients generally permitted the distinction from sickle cell anaemia (SS) but not necessarily from haemoglobin C disease (CC) or C/β thalassaemia. About half of the SC films showed characteristic SC poikilocytes and a minority also had some cells containing haemoglobin C crystals. In addition, SC differed from SS in having fewer classical sickle cells and nucleated red cells, more irregularly‐contracted cells and less polychromasia and evidence of hyposplenism.