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Acquired sideroblastic anaemia during treatment of Wilson's disease with triethylene tetramine dihydrochloride
Author(s) -
Condamine Luce,
Hermine Oliver,
Alvin Patrick,
Levine Martine,
Rey Caroline,
Courtecuisse Victor
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb04648.x
Subject(s) - tetramine , pyridoxine , sideroblastic anemia , medicine , gastroenterology , hemochromatosis , disease , anemia , chemistry
Summary We report one case of acquired sideroblastic anaemia in a patient treated for Wilson's disease with triethylene tetramine dihydrochloride (TTH). No other cause of acquired sideroblastic anaemia was found, and neither iron nor pyridoxine therapy could correct this anaemia. In contrast, decreasing the dose of TTH led to disappearance of ringed sideroblasts. Thus TTH should be added as a further cause of secondary acquired sideroblastic anaemia. The pathophysiology of this finding, probably linked to an abnormality of mitochondrial iron metabolism, is briefly discussed.