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Pure red cell aplasia of pregnancy: a distinct clinical entity
Author(s) -
Baker R. I.,
Manoharan A.,
De E.,
Begley C. G.
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03359.x
Subject(s) - pregnancy , medicine , aplasia , pure red cell aplasia , red blood cell , antibody , red cell , blood transfusion , gastroenterology , immunology , anemia , surgery , biology , genetics
Summary. We describe a 31‐year‐old patient with pure red cell aplasia of pregnancy, successfully managed with regular blood transfusions. In vitro studies showed specific inhibition of day 14 erythroid colonies (BFU‐E) using serum and purified immunoglobulin G (IgG) obtained from the patient at diagnosis (before blood transfusion). The inhibition of BFU‐E disappeared when haematological remission occurred 3 weeks after delivery and she remains clinically well with a normal haemoglobin 4 years later.