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Retinoic acid‐induced apoptosis and regression of a refractory Epstein‐Barr virus‐containing T cell lymphoma expressing multidrug‐resistance phenotypes
Author(s) -
Su IhJen,
Cheng AnnLii,
Tsai TsernFan,
Lay JongDing
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03235.x
Subject(s) - lymphoma , cancer research , chemotherapy , epstein–barr virus , virus , multiple drug resistance , drug resistance , biology , medicine , immunology , microbiology and biotechnology
Summary The virus‐associated T cell leukaemias/lymphomas are characterized by a poor prognosis primarily because of the rapid emergence of drug resistance which may lead to failure of subsequent chemotherapy. We report here a case of Epstein‐Barr virus‐associated T cell lymphoma which relapsed soon after chemotherapy and radiotherapy. The neoplastic cells of the relapsed tumour expressed high levels of multi‐drug resistance gene (mdr 1)‐related P‐glycoprotein and glutathione‐S‐transferase‐π, both of which were absent in the pre‐chemotherapy tumour tissues. Empirical treatment with oral 13‐cis‐retinoic acid (RA) was then given with subsequent complete disappearance of the tumour. The therapeutic effect of KA appears to act through an apoptotic process. In accordance with our previous report of a successful salvage of a refractory Ki‐1 large cell lymphoma. RA appears to be a potentially useful drug for some specific type T‐cell lymphomas.