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Nodular lymphocyte predominance Hodgkin's disease featuring blood atypical polyclonal B‐cell lymphocytosis
Author(s) -
Mariette Xaviek,
Tsapis Andréas,
Oksenhendler Eric,
Daniel MarieThérèse,
D'Agay MarieFrançoised,
Berger Roland,
Brouet JeanClaude
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03231.x
Subject(s) - lymphocytosis , polyclonal antibodies , lymph , pathology , lymphocyte , mantle zone , biology , population , lymphoproliferative disorders , immunology , gene rearrangement , medicine , lymphoma , b cell , antibody , gene , germinal center , genetics , environmental health
Summary The nodular lymphocyte predominance form of Hodgkin's disease (NLPHD) is considered as a B cell derived lymphoproliferative disease. A patient with NLPHD presented with an absolute increase in blood B cells with cytological features of mantle zone cells: these B cells were polyclonal, did not exhibit bcl‐2 gene rearrangement. and some of them displayed non‐clonal chromosomal aberrations. EB virus genome was not detected by Southern analysis. Thus, this study, taking advantage of the presence of an unusual population of blood atypical B cells, confirms data obtained on lymph nodes where, however, malignant cells may be scarce, indicating that NLPHD is a polyclonal B cell lymphoproliferative disease of mantle zone origin.