Premium
Contamination of peripheral blood by monoclonal B cells following treatment of multiple myeloma by high‐dose chemotherapy
Author(s) -
Dreyfus François,
Melle Josiane,
Quarre MarieCatherine,
Pillier Catherine
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03188.x
Subject(s) - apheresis , multiple myeloma , monoclonal , chemotherapy , medicine , monoclonal antibody , peripheral blood , hematology , immunology , population , antibody , platelet , environmental health
Summary Peripheral blood samples obtained from five patients with multiple myeloma, after high‐dose chemotherapy, were studied for monoclonal B plasma cell contamination. We used the technique of immunoglobulin heavy chain gene ‘fingerprinting’ at the time of diagnosis and during apheresis. The level of sensitivity of this technique is between 041% and 0.001% in two patients in whom a monoclonal population was detected in peripheral blood.