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Reversing of chlorambucil resistance by ethacrynic acid in a B‐CLL patient
Author(s) -
Petrini M.,
Conte A.,
Caracciolo F.,
Sabbatini A.,
Grassi B.,
Ronca G.
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03187.x
Subject(s) - chlorambucil , reversing , glutathione , chemistry , medicine , pharmacology , biochemistry , chemotherapy , enzyme , materials science , composite material , cyclophosphamide
Summary We evaluated the reversing activity of ethacrynic acid in a B‐CLL patient resistant to chlorambucil. The glutathione S‐transferase (GST) activity, measured in peripheral blood lymphocytes, resulted extremely elevated. Etha crynic acid, at pharmacological concentrations, partially reversed chlorambucil resistance and this result appeared related to the increased GST levels.