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The inter‐relationship of factor VII and its activity state with plasma lipids in healthy male adults
Author(s) -
Wright D.,
Poller L.,
Thomson J. M.,
Gowland E.,
Burrows G. E.
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03177.x
Subject(s) - factor vii , medicine , thromboplastin , endocrinology , cholesterol , clotting factor , factor x , chemistry , coagulation , tissue factor , apolipoprotein b , blood plasma , clotting time , factor ix , platelet , thrombin
Summary A close inter‐relationship between raised factor VII clotting activity and elevated blood lipids, particularly serum triglycerides, is well established. A study of factor VII, its activation state and of plasma lipids has been undertaken in two groups of healthy middle‐aged males to elucidate this mechanism. A control group with normal factor VII levels were closely matched for age and body‐mass index with a second group with elevated levels. Factor VII assays, using rabbit and bovine thromboplastin and a factor VII Ag method, were employed. Triglycerides correlated with the rabbit factor VII thromboplastin assay and factor VII Ag ( P <0.05) but not with the bovine thromboplastin method. Higher HDL‐cholesterol and apolipoprotein A‐I levels were found in subjects with increased factor VII ( P <0.001) and appeared to be due to differences in alcohol consumption. Cholesterol levels were significantly higher with elevated factor VII. Differential testing suggests that higher factor VII is predominantly mediated through a rise in total VII, rather than an increase in its activity state.