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Leukaemia arising in donor cells following allogeneic bone marrow transplantation for β thalassaemia demonstrated by immunological, DNA and molecular cytogenetic analysis
Author(s) -
Katz Fay,
Reeves B. R.,
Alexander Shirley,
Kearney Lyndal,
Chessells Judith
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03174.x
Subject(s) - bone marrow , human leukocyte antigen , immunology , medicine , bone marrow transplantation , transplantation , hematology , cancer research , biology , antigen
Summary Combined DNA analysis, molecular cytogenetic and immunological techniques have been used to identify the donor origin of common acute lymphoblastic leukaemia (cALL) which arose in a male patient with β thalassaemia major, 5 years after an allogeneic bone marrow transplant from his HLA‐matched sister. The necessity of using multiple techniques in this and similar cases is emphasized and the possible mechanisms for the development of donor leukaemia and the leukaemic transformation of donor cells are discussed.