Premium
Serum deoxythymidine kinase: no help in the diagnosis and prognosis of monoclonal gammopathy
Author(s) -
Bäck Hans,
Jagenburg Rudolf,
Rödjer Stig,
Westin Jan
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03156.x
Subject(s) - monoclonal gammopathy , monoclonal gammopathy of undetermined significance , multiple myeloma , medicine , monoclonal , gammopathy , monoclonal antibody , paraproteinemias , pathology , immunology , antibody
Summary. Serum deoxythymidine kinase activity (S‐TK) was determined in the diagnostic evaluation and follow‐up of patients with monoclonal gammopathy of undetermined significance (MGUS). During a 4‐year period 35 patients were included in the study. Normal concentrations of S‐TK were found in 33. Patients with non‐progressive monoclonal gammopathy kept a stable, and for the individual, a characteristic level of S‐TK during several years of follow‐up. A moderately elevated level of S‐TK during observation did not indicate progression. Even in four out of five patients developing symptomatic multiple myeloma S‐TK remained unchanged. Determination of S‐TK does not give diagnostic or prognostic information in monoclonal gammopathy.