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Myelodysplastic syndrome with eosinophilia in bone marrow
Author(s) -
Matsushima Takafumi,
Murakami Hirokazu,
Sawamura Morio,
Tamura Jun'ichi,
Sakura Tohru,
Matsumoto Morio,
Hirabayashi Hisami,
Miyawaki Shuichi,
Simano Shunichi,
Sato Sadao,
Tsuchiya Jun
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03139.x
Subject(s) - eosinophilia , bone marrow , myelodysplastic syndromes , medicine , cytogenetics , pathology , karyotype , dysplasia , cytopenia , bone marrow failure , refractory anemia , gastroenterology , haematopoiesis , stem cell , biology , chromosome , biochemistry , genetics , gene
Summary. Clinical features were investigated in 114 patients with de novo myelodysplastic syndrome (MDS) diagnosed over the past 10 years, and eight cases (7%) were complicated with eosinophilia in the bone marrow. Two patients had refractory anaemia (RA), five had RA with excess of blasts (RAEB), and one had RAEB in transformation. Their bone marrow cells exhibited trilineage dysplasia and morphological abnormalities in eosinophils. Cytogenetics revealed major karyotype abnormalities (MAKA) in five patients. Survival durations were significantly shorter than those of other MDS patients. Our study suggests that marrow eosinophilia in MDS is strongly related to the coexistence of MAKA.