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The bone marrow in murine AIDS
Author(s) -
Magnani Mauro,
Brandi Giorgio,
Rossi Luigia,
Carnevali Andrea,
Fraternale Alessandra,
Albano Amedeo
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03116.x
Subject(s) - bone marrow , histiocyte , eosinophil , medicine , immunology , retrovirus , immunostaining , pathology , virology , virus , immunohistochemistry , asthma
Summary. In order to increase the understanding of blood cytopenias in HIV infection we have investigated the bone marrow in murine AIDS. C57BL/6 mice infected with the LP‐BM5 retrovirus show a decrease in cellularity, numerous haemophagocytic histiocytes, a reduction of all erythroid precursor cells, an increase in eosinophil number and an increase in lymphocytes. Immunostaining with an anti‐Pr60 gag antibody shows that the majority of bone marrow cells express the viral protein. Thus, the bone marrow in MAIDS has many similarities with the bone marrow from patients with advanced AIDS and may prove useful as a model for therapy aimed at treating blood cytopenias.