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Parvovirus B19‐associated haemophagocytosis in Evans syndrome: aplastic crisis accompanied by severe thrombocytopenia
Author(s) -
Uike Naokuni,
Miyamura Tomoya,
Obama Kohsuke,
Takahira Hiroyuki,
Sato Hiroyuki,
Kozuru Mitsuo
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03113.x
Subject(s) - parvovirus , histiocyte , immunology , medicine , evans syndrome , platelet , bone marrow , virus , pathology , antibody , autoimmune hemolytic anemia
Summary. A 36‐year‐old man who had been treated for Evans syndrome (ES) developed an aplastic crisis caused by acute human parvovirus B19 (HPV) infection. Profound thrombocytopenia (8·0 × 10 9 /l) followed with a sudden increase in platelet‐associated IgG (PAIgG) (1376·9 ng/10 7 plts). Bone marrow examination revealed a considerable number of haemophagocytic histiocytes without any disturbance of megakaryopoiesis. To our knowledge this is the first case of aplastic crisis with virus‐associated haemophagocytosis in a patient with ES, which provides an interesting insight into the mechanisms for thrombocytopenia in HPV infection.