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A tumour‐associated antigen expression in human haematological malignancies
Author(s) -
Chambost H.,
Brasseur F.,
Coulie P.,
Plaen E.,
Stoppa A. M.,
Baume D.,
Mani P.,
Boon T.,
Maraninchi D.,
Olive D.
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03111.x
Subject(s) - antigen , immunology , gene , biology , cancer research , gene expression , medicine , genetics
Summary. Objective responses obtained with high‐dose in vivo recombinant interleukin 2 (r‐IL2) in some leukaemic patients suggest among other hypotheses that blasts might express tumour rejection antigens potentially recognized by cytolytic T lymphocytes. Such antigens have been described in human melanomas and the MAGE‐1 gene, coding for a tumour rejection antigen was recently identified. This gene is expressed in various solid tumours, but not in normal cells. We have screened a panel of haematological malignancies by reverse transcription and PCR and we report that MAGE‐1 is not expressed in the blasts from 48 patients whereas three cell lines derived from leukaemias express this gene.