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Alpha interferon raises serum beta‐2‐microglobulin in patients treated for thrombocythaemia
Author(s) -
Remes K.,
Tienhaara A.,
Pelliniemi TT.
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03082.x
Subject(s) - beta 2 microglobulin , medicine , beta (programming language) , alpha interferon , gastroenterology , interferon , immunology , computer science , programming language
Summary. Serum beta‐2‐microglobulin (b2m) levels were studied in 10 patients treated with alpha interferon (IFN) for thrombocythaemia associated with chronic myeloproliferative diseases. In eight patients the IFN treatment decreased the blood platelet level to <600 × 10 9 /1. Serum b2m levels rose significantly and dose‐dependently immediately after the onset of treatment, by a median maximal increase of 72% with IFN 3 MU every other day, and 95% with 3 MU daily. The b2m rise caused by IFN abolishes the value of serum b2m in states where b2m is used as an indicator of disease activity.