Premium
BCR‐ABL rearrangement in a child with acute myelogeneous leukaemia without a Philadelphia chromosome
Author(s) -
Borkhardt A.,
Repp R.,
Harbott J.,
Lakomek M.,
Janssen J. W. G.,
Schlieben S.,
Bartram C. R.,
Lampert F.
Publication year - 1993
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1993.tb03077.x
Subject(s) - incidence (geometry) , medicine , breakpoint cluster region , philadelphia chromosome , gene rearrangement , pediatrics , chromosomal translocation , genetics , biology , gene , physics , receptor , optics
Summary. We describe a BCR/ABL rearrangement positive but Philadelphia chromosome negative status in a 9‐year‐old boy suffering from an acute myelogeneous leukaemia (AML). This case was detected in a prospective PCR screening procedure including 21 children with newly diagnosed AML and 150 children with acute lymphoblastic leukaemia (ALL). We found a 5·4% incidence of BCR/ABL rearrangement positive cases in pre‐B and c‐ALL in childhood.