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Plasmodium falciparum : diversity of isolates from Malawi in their cytoadherence to melanoma cells and monocytes in vitro
Author(s) -
Goldring J. D.,
Molyneux M. E.,
Taylor T.,
Wirima J.,
Hommel M.
Publication year - 1992
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1992.tb08249.x
Subject(s) - plasmodium falciparum , u937 cell , in vitro , biology , hela , cell culture , monocyte , melanoma , virology , cell , microbiology and biotechnology , immunology , malaria , cancer research , biochemistry , genetics
We observed considerable diversity in the cytoadherence of Plasmodium falciparum isolates from Malawi to melanoma cells, U937 cells and human peripheral monocytes. Each isolate exhibited a unique cytoadherence profile for the three human cell types. These isolates generally adhered well to U937 cells and fresh monocytes, moderately to melanoma cells and poorly to TE 671, MIA‐Pa‐Ca, WI 38, PLC/PRF/5 and HeLa cells. An antimalarial immunoglobulin pool inhibited binding to melanoma cells by 50% or more and to U937 cells by 25% or less. There was no correlation between in vitro cytoadherence to the three cells and clinical disease. These results suggest that malarial adherence ligands exposed on the surface of infected erythrocytes vary from one isolate to another.