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Childhood polyclonal T cell lymphocytosis with neutropenia: effects of antilymphocyte globulin and granulocyte colony stimulating factor in vitro and in vivo
Author(s) -
Laurie A. S.,
Gibson F. M.,
Josten K. M.,
Talbot P. J.,
Rutherford T. R.,
Lilleyman J. S.,
GordonSmith E. C.
Publication year - 1992
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1992.tb04556.x
Subject(s) - granulopoiesis , neutropenia , lymphocytosis , immunology , granulocyte colony stimulating factor , medicine , granulocyte , progenitor cell , bone marrow , in vivo , biology , toxicity , chemotherapy , stem cell , genetics , microbiology and biotechnology
Summary The pathogenesis of the neutropenia that occurs in some patients with chronic T cell lymphocytosis is not well understood. We have investigated a 15‐year‐old girl with this syndrome. Initial committed bone marrow progenitor numbers (CFUgm) were low but markedly increased in vitro following T cell depletion. Similarly a transient correction of neutropenia was observed following in vivo lymphocyte depletion with antilymphocyte globulin. A sustained neutrophil recovery was achieved with daily therapy using recombinant human granulocyte colony stimulating factor (rhG‐CSF) despite persistence of the lymphocytosis; during successful therapy CFUgm numbers remained low, and were not increased by the in vitro addition of rhG‐CSF. These observations suggest the possibility of an inhibitory regulatory mechanism specifically acting on neutrophil granulopoiesis.