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Two myelodysplastic syndrome cases with the inv(ll)(pl5q23) as a sole chromosomal abnormality
Author(s) -
Mitani Kinuko,
Sato Yuko,
Hayashi Yasuhide,
Miura Yasusada,
Miyagawa Kiyoshi,
Yazaki Yoshio,
Hirai Hisamaru
Publication year - 1992
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1992.tb02983.x
Subject(s) - chromosomal abnormality , abnormality , myelodysplastic syndromes , medicine , genetics , karyotype , dermatology , biology , pathology , bone marrow , chromosome , psychiatry , gene
Two myelodysplastic syndrome cases (one with acute nonlymphocytic leukaemia (M2) transformed from myelodysplastic syndrome (MDS), and the other with chronic myelomonocytic leukaemia following refractory anaemia with excess of blasts in transformation) showed the inv(11)(p15q23) as a sole chromosomal abnormality. Gene probes for c‐Ha‐ ras ‐1 and c‐ets ‐1 were hybridized to meta‐phase cells from bone marrow of these patients, c‐ets ‐1 gene, which is mapped to 11q23, was demonstrated to have translocated to the short arm in the rearranged chromosome 11 in both cases. On the other hand, c‐Ha‐ ras ‐1 gene, which is located at 11p15, was translocated to the long arm in the rearranged chromosome 11 in patient 1, and deleted in patient 2. Our findings suggest that there may be heterogeneity in molecular events involved in the chromosomal rearrangement among the inv(11)‐carrying MDS.