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Autoantibodies and drug‐or metabolite‐dependent antibodies in patients with diclofenac‐induced immune haemolysis
Author(s) -
Salama A.,
Göttsche B.,
MuellerEckhardt C.
Publication year - 1991
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1991.tb08624.x
Subject(s) - antibody , drug , autoantibody , haemolysis , diclofenac , medicine , immunology , metabolite , immune system , ex vivo , antigen , pharmacology , in vivo , drug metabolism , biology , microbiology and biotechnology
S ummary . Two patients with acute immune haemolytic anaemia caused by diclofenac are described. Both patients had developed IgG drug‐independent autoantibodies and drug‐dependent antibodies. The drugdependent antibodies in one patient reacted with red blood cells (RBC) only in the presence of urine from patients receiving diclofenac ( ex vivo antigen) but not in the presence of the drug itself or its known metabolites. This antibody appeared to recognize a trace metabolite which has not yet been identified. The drug‐dependent antibodies in the second patient reacted with RBC in the presence of urine as ex vivo antigen as well as in the presence of the drug itself and its main metabolites. Incorrect diagnosis of such cases often is due to the occurrence of autoantibodies and/or unusual drug metabolism and excretion.