Premium
Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors
Author(s) -
Littlewood Janet D.,
Bevan Sally A.,
KemballCook Geoffrey,
Evans Richard J.,
Barrowcliffe Trevor W.
Publication year - 1991
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1991.tb08622.x
Subject(s) - monoclonal antibody , phospholipid , antibody , chemistry , human plasma , microbiology and biotechnology , immunology , pharmacology , biochemistry , biology , chromatography , membrane
S ummary . The source of human factor VIIII (FVIII) had a marked effect on the inhibitory activity of a panel of eight human FVIII inhibitors. Use of conventional FVIII concentrates gave lower inhibitor titres whereas a monoclonal antibody purified FVIII concentrate gave titres similar to or greater than those with plasma. Addition of phospholipid (PL) protected highly purified FVIII against inhibition. The content of PL‐bound FVIII in concentrates may account for the observed differences.