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Fanconi's anaemia and pregnancy
Author(s) -
Alter Blanche P.,
Frissora Christine L.,
Halpéirin Daniel S.,
Freedman Melvin H.,
Chitkara Usha,
Alvarez Emanuel,
Lynch Lauren,
AdlerBrecher Barbara,
Auerbach Arleen D.
Publication year - 1991
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1991.tb08593.x
Subject(s) - pregnancy , medicine , fanconi anemia , obstetrics , pediatrics , biology , genetics , dna , dna repair
Summary We have identified six new cases of Fanconi's anaemia (FA) who had pregnancies, and reviewed 11 others from the literature. At least 110 FA females have reached 16 years of age or more, of whom 15% became pregnant. There were a total of 26 pregnancies, resulting in 19 births and 18 surviving children. Anaemia and/or thrombocytopenia worsened during pregnancy in 10 patients, but five subsequently improved: seven had no haematological problems. Seven of the FA patients who had pregnancies died subsequently from cancer, and two from thrombocytopenic bleeding 3 and 20 years later. There were no peripartum deaths. Pregnancy in FA is clearly possible, with increased risks that are manageable from both the haematological and the obstetric aspects.