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Colony‐cluster ratio and cluster number in cultures of circulating myeloid progenitors as indicators of high‐risk myelodysplasia
Author(s) -
Tennant G. B.,
Bowen D. T.,
Jacobs A.
Publication year - 1991
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1991.tb08574.x
Subject(s) - medicine , myelodysplastic syndromes , progenitor cell , myeloid , cluster (spacecraft) , gastroenterology , refractory anemia , survival analysis , refractory (planetary science) , immunology , bone marrow , biology , stem cell , genetics , astrobiology , computer science , programming language
Summary Circulating myeloid progenitors were assayed in 172 normal subjects and 147 patients with myelodysplastic syndrome (MDS). Patients whose cultures had colony/cluster ratios (CCR) < 0·3 had significantly shorter survival periods than comparable patients with CCR > 0·3. A second prognostic indicator, which complemented CCR, was identified in patients with < 5% blasts. Median survival was significantly reduced in patients with > 15 clusters/ml blood despite colony and cluster numbers being predominantly within the normal range. Characteristic differences were found in three FAB groups large enough to allow statistical analysis. Survival amongst patients with refractory anaemia with excess of blasts (RAEB) was related to CCR and was independent of cluster number. Amongst sideroblastic patients (SA) survival related only to cluster number. Refractory anaemia (RA) patients included individuals in both high‐risk groups with only three patients out of 64 showing both features. Amongst all the MDS patients, those with CCR > 0·3 and < 15 clusters/ml blood formed a low‐risk group ( n = 60) with a relatively good prognosis of whom 85% survived the study period (median duration 938 d) including 94% of those in this group with < 5% marrow blast cells.