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Biological significance of cell cycle kinetics in 128 standard risk newly diagnosed patients with acute myelocytic leukaemia
Author(s) -
Raza Azra,
Preisler Harvey,
Lampkin Beatrice,
Yousuf Naveed,
Tucker Christopher,
Peters Nancy,
White Michael,
Kukla Cathy,
Gartside Peter,
Siegrist Carl,
Bismayer John,
Barcos Maurice,
Bennett John,
Browman George,
Goldberg Jack,
Grunwald Hans,
Larson Richard,
Vardiman James,
Vogler Ralph
Publication year - 1991
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1991.tb08003.x
Subject(s) - thymidine , medicine , cell cycle , bone marrow , gastroenterology , bromodeoxyuridine , anthracycline , nuclear medicine , immunology , in vitro , biology , biochemistry , cancer , immunohistochemistry , breast cancer
Bromodeoxyuridine (BrdU) was administered to 128 newly diagnosed patients with standard risk acute myelocytic leukaemia (AML) for cell cycle measurements. Labelling indices (LI) were obtained from both the bone marrow aspirate (BMasp) and biopsies (bx) and durations of S‐phase ( T s ) and total cell cycle time ( T c ) were measured by double‐labelling the S‐phase cells in vitro with tritiated thymidine. Median LI BMasp was 8% and from BMbx was 25%. The median T s was 12 h (range 3·1–35 h) and T c was 48 h (range 11·5–211 h). All patients received induction therapy with a combination of cytosine arabinoside and an anthracycline. Outcome of therapy or FAB type were not related to cell cycle characteristics. Patients with above median LI BMasp, however, had longer remission durations ( P = 0·03) as did patients with above median T s ( P = 0·03) and T c ( P = 0·03). Upon longer follow‐ups, even some of the patients with slowly cycling myeloblasts have relapsed (log rank P = 0·453 and 0·203 for T s and T c respectively). We conclude that patients with rapidly cycling cells tend to relapse faster; however, slowly cycling nature of myeloblasts is not associated with curability.