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Expression of triplicated and quadruplicated α globin genes in sheep
Author(s) -
Vestri R.,
Pieragostini E.,
Yang F.,
Gregorio P. di,
Rando A.,
Masina P.
Publication year - 1991
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1991.tb07956.x
Subject(s) - gene , globin , biology , genetics , gene expression , microbiology and biotechnology , computational biology
Summary. In the sheep ααα globin gene haplotype, the three genes display from the 5′ to the 3′ end the percentage efficiencies of about 30:14:6, as indicated by the amounts of the three types of α chain produced in the ααα/ααα homozygotes. The 3′ gene in the αααα haplotype appears to have an efficiency around 1%, as suggested by analysis of one quadruple a homozygote. Moreover, the total outputs of the ααα as well as of the αααα haplotypes do not substantially differ from that of the common αα haplotype.