Premium
Characterization of leukaemic basophil progenitors from chronic myelogenous leukaemia
Author(s) -
Teshima Takanori,
Kondo Seiji,
Harada Mine,
Shibuya Tsunefumi,
Okamura Takashi,
Tamari Yuichi,
Kimura Nobuhiro,
Akashi Koichi,
Okamura Seiichi,
Niho Yoshiyuki
Publication year - 1991
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1991.tb04382.x
Subject(s) - chronic myelogenous leukemia , basophil , progenitor cell , immunology , medicine , leukemia , cancer research , biology , stem cell , genetics , antibody , immunoglobulin e
Summary We describe the unique characteristics of leukaemic basophils from a patient with chronic myelogenous leukaemia (CML). The leukaemic cells were immature basophil‐like blasts and expressed CD4, CD7 and HLA‐DR in addition to CD13 and CD33. Both immunoglobulin and T cell receptor genes were retained in germline configurations. Interleukin‐1 (IL‐1) or granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) as well as IL‐3 or IL‐4 enhanced the proliferation and differentiation of leukaemic cells and only basophils were generated from in vitro culture. These results suggest that basophil progenitors expressing CD4, CD7 and HLA‐DR may be involved in the development of basophilic crisis of CML and that both IL‐1 and GM‐CSF may act on basophil progenitors as well as IL‐3 or IL‐4.