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Histocompatibility antigen patterns in haemophilic patients with factor VIII antibodies
Author(s) -
Aly Ashraf M.,
Aledort Louis M.,
Lee Tsung D.,
Hoyer Leon W.
Publication year - 1990
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1990.tb07878.x
Subject(s) - haemophilia , haemophilia a , antibody , human leukocyte antigen , immunology , antigen , medicine , histocompatibility , typing , haemophilia b , isoantibodies , factor ix , biology , genetics , pediatrics
S ummary A number of studies suggest that there is a genetic basis for the formation by some haemophilia A patients of antibodies that inactivate factor VIII. In our study, human leucocyte antigen (HLA)‐A, B. C, DR and DQ typing was carried out for 44 haemophilia A patients, including 16 who had developed an antibody to factor VIII. In contrast to previous reports, we found no association between HLA‐DR antigens and haemophilia A per se or the formation of a factor VIII inhibitor. However, there was an absence of HLA‐Cw5 in the 16 haemophilic patients who had formed an antibody to factor VIII. This finding, consistent with a previous report, identified a statistically significant difference in HLA‐Cw5 frequency when the inhibitor patient group was compared to multi‐transfused haemophilic patients who had no inhibitor (11/28).