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Interleukin 5 activity in sera from patients with eosinophilia
Author(s) -
Enokihara Hideo,
Kajitani Hiroshi,
Nagashima Shigeki,
Tsunogake Satoshi,
Takano Naoto,
Saito Kenji,
Furusawa Shimpei,
Shishido Hideo,
Hitoshi Yasumichi,
Takatsu Kiyoshi
Publication year - 1990
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1990.tb07782.x
Subject(s) - eosinophilia , eosinophil , interleukin 5 , medicine , immunology , prednisolone , antibody , interleukin , eosinophilic , stimulation , cytokine , pathology , asthma
S ummary . Sera from 10 patients with eosinophilia contained eosinophil colony stimulating factor (Eo‐CSF) activity. Using anti murine (m) interleukin‐5 (IL‐5) antibody, we demonstrated that this activity was mainly derived from IL‐5. Administration of prednisolone to patients decreased both Eo‐CSF activity in sera and the number of eosinophils in blood. These results extend our recent study demonstrating that T cells from eosinophilic patients produce IL‐5 with IL‐2 stimulation and may support the speculation that IL‐5 is an important factor which induces eosinophilia.