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Correlation of chromosome abnormalities with laboratory features and clinical course in B‐cell chronic lymphocytic leukaemia
Author(s) -
Oscier D. G.,
Stevens J.,
Hamblin T. J.,
Pickering R. M.,
Lambert R.,
Fitchett M.
Publication year - 1990
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1990.tb06367.x
Subject(s) - karyotype , chromosome abnormality , pathology , abnormality , chronic lymphocytic leukemia , chromosome , medicine , cytogenetics , immunology , gastroenterology , biology , leukemia , genetics , psychiatry , gene
Summary 141 patients with B‐cell chronic lymphocytic leukaemia (B‐CLL) have been studied for a minimum of 12 months and a maximum of 25 years. 30 of 133 patients (32·5%) had greater than 10% FMC7 positive peripheral blood lymphocytes and 19 of 131 patients (14·5%) had a serum or urinary paraprotein. At presentation 88 patients were stage A0, 18 A1, 18A2, 11B and six C. 44 (31%) had progressive disease and 42 (30%) died during the study period. 63 patients had a normal karyotype, 75 a clonal abnormality and in three no metaphases were obtained. The finding of a complex karyotypic abnormality was significantly associated with λ surface phenotype ( P <0·01), and the presence of > 10% FMC7 positive cells ( P <0·025), and the presence of a paraprotein ( P <0·025). Patients whose leuk‐aemic cells had a complex karyotype and those with stuuctural abnormalities of chromosomes 14 and 6 required treatment earlier than those with a normal karyotype.