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Prognostic factors in stage AO B‐cell chronic lymphocytic leukaemia
Author(s) -
Oscier D. G.,
Stevens J.,
Hamblin T. J.,
Pickering R. M.,
Fitchett M.
Publication year - 1990
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1990.tb06366.x
Subject(s) - medicine , stage (stratigraphy) , chronic lymphocytic leukemia , lymphocyte , immunology , karyotype , antibody , surface immunoglobulin , disease , gastroenterology , b cell , biology , leukemia , chromosome , genetics , paleontology , gene
Summary 85 patients presenting to a single centre with stage AO B‐cell chronic lymphocytic leukaemia (B‐CLL) have been studied. The duration of follow‐up has ranged from a minimum of 1 year to a maximum of 18 years with a mean of 6 years. 14 patients have had progressive disease and 23 patients have died, of whom nine had CLL‐related deaths. We assessed the prognostic significance of the following parameters: age at presentation, sex, haemoglobin concentration, initial lymphocyte count, surface membrane phenotype. serum immunoglobulin levels at presentation and karyotype. None of these factors were predictive of survival, but there was a correlation between initial lymphocyte count, surface immunoglobulin MDλ phenotype, and complex karyotypic abnormalities and disease progression. Two patients with a complex karyotype have been followed for more than 5 years without evidence of progression.