Premium
Studies of an oral iron chelator: 1,2 ‐dimethyl‐ 3 ‐hydroxy‐pyrid‐4‐one I. IRON EXCRETION IN RATS: DEVELOPMENT OF A NEW RAPID MICROWAVE METHOD FOR IRON ANALYSIS IN FAECES
Author(s) -
Venkataram S.,
Rahman Y. E.
Publication year - 1990
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1990.tb02662.x
Subject(s) - excretion , urine , feces , chemistry , oral administration , subcutaneous injection , pharmacology , chelation , absorption (acoustics) , route of administration , biochemistry , medicine , biology , materials science , inorganic chemistry , composite material , paleontology
Summary We have developed a simple, rapid method for analysing faecal iron using a microwave oven for digestion followed by atomic absorption spectrometry. The chelating effect of l,2‐dimethyl‐3‐hydroxy‐pyrid‐4‐one (DMHP) has been tested in rats with experimental iron overloading and three routes of DHMP administration, oral, subcutaneous, and intraperitoneal, have been compared. Regardless of the route of administration, we have found that DMHP promotes iron excretion via the urine. We have not observed a difference in the amount of iron excreted in the faeces before and after DMHP administration by any route. The subcutaneous route of administration is the most effective in promoting iron excretion, followed by the intraperitoneal route. Although most convenient for clinical use, oral administration promotes the excretion of only a small fraction of that by the subcutaneous route.