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Infant acute lymphoblastic leukaemia with t(11;19)
Author(s) -
Gibbons B.,
Katz F. E.,
Ganly P.,
Chessells J. M.
Publication year - 1990
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1990.tb02581.x
Subject(s) - organomegaly , medicine , acute lymphocytic leukemia , hematology , disease , immunology , pediatrics , lymphoblastic leukemia , leukemia
Summary Seven cases of infant acute lymphoblastic leukaemia with t(11:19) (q23;p13) are described. They are characterized by a high white cell count, organomegaly, early central nervous system (CNS) disease, and a poor prognosis. Blasts are usually of an immature early B‐cell lineage although monocytoid features are present in some cases. The characteristics of infant acute leukaemia with t(11;19) are very similar to those found with t(4;11), and the presence of t(11;19) may indicate the same poor prognosis.