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Induction of eosinophilic colonies by interleukin‐5 on acute myeloblastic leukaemic cells
Author(s) -
Motoji Toshiko,
Okada Michiko,
Takanashi Minoko,
Masuda Michihiko,
Tanaka Kumi,
Oshimi Kazuo,
Mizoguchi Hideaki
Publication year - 1990
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1990.tb02561.x
Subject(s) - acute myeloblastic leukemia , eosinophil , eosinophilic , precursor cell , progenitor cell , immunology , interleukin 5 , biology , interleukin , interleukin 3 , stem cell , leukemia , cell , cytokine , microbiology and biotechnology , immune system , interleukin 21 , t cell , genetics , asthma
Summary The effect of interleukin‐5 (IL‐5) on blast colony formation of acute myeloblastic leukaemia (AML) cells was studied. IL‐5 showed a weak but significant colony stimulatory effect in one out of six cases studied. IL‐5 induced eosinophilic colony growth in this case, and chromosomal and histochemical analyses strongly suggested that these eosinophilic colonies were derived from leukaemic blast progenitor cells. To our knowledge, this is the first report that IL‐5 induces eosinophilic colonies on fresh AML cells. A possible induction of differentiation of AML blast cells by IL‐5 is suggested.