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Prevalence of monoclonal Ig with λ light chains in chronic myelocytic leukaemia
Author(s) -
Guglielmi P.,
Davi F.,
Brouet J. C.
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb07748.x
Subject(s) - immunoglobulin light chain , isotype , monoclonal , monoclonal antibody , multiple myeloma , breakpoint cluster region , microbiology and biotechnology , medicine , immunology , biology , antibody , receptor
Summary Light chains from seven of eight monoclonal Ig detected in the serum of patients with chronic myelocytic leukaemia (CML) were of the λ isotype. Although the presence of monoclonal Ig in CML is distinctly unusual, this prevalence of λ chains is unlikely to be a mere coincidence. All patients had otherwise typical clinical, chromosomal and molecular (bcr rearrangements) features of classical CML. The λ locus appeared unaltered. Only two patients had an excess of dystrophic plasma cells suggestive of multiple myeloma.