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Biological and clinical features of acute lymphoblastic leukaemia with cytoplasmic granules or inclusions: description of eight cases
Author(s) -
CantùRajnoldi Angelo,
Invernizzi Rosangela,
Biondi Andrea,
Banfi Patrizio,
Zoia Adele,
Fazio Pasqualina De,
Polli Nicoletta
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb07745.x
Subject(s) - immunophenotyping , cytoplasmic inclusion , cytoplasm , calla , acute lymphocytic leukemia , cd33 , pathology , cd20 , gene rearrangement , incidence (geometry) , ultrastructure , cd19 , medicine , biology , immunology , antigen , leukemia , gene , lymphoblastic leukemia , antibody , biochemistry , immunohistochemistry , microbiology and biotechnology , stem cell , cd34 , optics , monoclonal antibody , physics
Summary We describe eight patients (four children and four adults) with an acute lymphoblastic leukaemia (ALL) with cytoplasmic granules or inclusions. The incidence of this variant of acute leukaemia in our whole series of patients with ALL is 1.8%. The granules or inclusions were usually positive for aspecific esterases (ANAE) and/or acid phosphatase, and the immunophenotype was in all cases typical of a CALLA positive B‐lineage ALL (CD10 + , CD19 + and/or CD24 + , DR + , TdT + , anti‐T ‐ , anti‐My ‐ , SIg ‐ ). In one paediatric case, CD33 was unusually coexpressed. Ultrastructural investigations were performed in one case and demonstrated large granules containing vesicles, usually membrane bound, in the majority of blast cells. In the two cases analysed, Ig heavy chain gene rearrangement was detected. In this series of patients prognosis was poor since three never achieved a complete remission, four relapsed and only one is still in first continuous remission.