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Increased in vivo biosynthesis of prostacyclin and thromboxane A2 in chronic idiopathic thrombocytopenic purpura
Author(s) -
Rousson D.,
Guichardant M.,
Lagarde M.,
Viala J. J.,
Dechavanne M.
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb07723.x
Subject(s) - platelet , thromboxane a2 , prostacyclin , medicine , thrombocytopenic purpura , urinary system , in vivo , thromboxane b2 , endocrinology , gastroenterology , chemistry , biology , microbiology and biotechnology
Summary. The production of thromboxane A 2 (TxA 2 ) and prostacyclin (PGI 2 ) was studied in patients with chronic idiopathic thrombocytopenic purpura (10 patients) compared to central thrombocytopenia (five patients) and healthy subjects (10 subjects). This production was monitored by the assay of urinary 2,3‐dinor‐TxB 2 and 2,3‐dinor‐6‐keto‐PGF 1α as respective breakdown products of TxA 2 and PGI 2 by stable isotope dilution assays employing negative ion‐chemical gas‐chromatography‐mass‐spectrometry. Evidence is presented for the existence of an enhanced PGI 2 and TxA 2 urinary excretion in the group of idiopathic thrombocytopenic purpura (ITP) patients. Moreover, production of serum TxB 2 per platelet was decreased in ITP group. These results provide arguments for an in vivo platelet cyclooxygenase hyperactivity during chronic ITP.