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Dyserythropoiesis and ineffective erythropoiesis in Plasmodium vivax malaria
Author(s) -
Wickramasinghe S. N.,
Looareesuwan Sornchai,
Nagachinta Bussarin,
White N. J.
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb07658.x
Subject(s) - erythropoiesis , ineffective erythropoiesis , bone marrow , malaria , immunology , biology , plasmodium vivax , pathology , plasmodium falciparum , anemia , medicine
Summary. Nine Thai adults with P. vivax malaria were investigated. Light and electron microscope studies of marrow aspirates revealed morphological evidence of dyserythro‐poiesis in six of them, Dyserythropoiesis was most marked in the four most anaemic patients. In these four patients the electron microscope also revealed the presence of erythro‐blasts at various stages of degradation within the cytoplasm of macrophages. Neither the dyserythropoiesis nor the ineffective erythropoiesis could be attributed to a deficiency of vitamin B 12 , folate or iron. The abnormalities of erythropoiesis seemed to result from the P. vivax infection itself. Other bone marrow reactions seen in this infection included macrophage hyperplasia, plasmacytosis and increased eosinophil granulocytopoiesis. Unlike in severe P. falciparum malaria, the microvasculature of the marrow was not obstructed by parasitized red cells.