Premium
Fetal and neonatal von Willebrand factor (vWF) is unusually large and similar to the vWF in patients with thrombotic thrombocytopenic purpura
Author(s) -
Weinstein Mark J.,
Blanchard Rita,
Moake Joel L.,
And Evan Vosburgh,
MOISE Kenneth
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb07654.x
Subject(s) - von willebrand factor , medicine , platelet , fetus , thrombotic thrombocytopenic purpura , cryoprecipitate , cord blood , umbilical cord , endocrinology , coagulation , immunology , pregnancy , biology , genetics
Summary. We have investigated the distribution of vWF multimers in blood from the umbilical cord of infants delivered vaginally and by caesarean section, from heel‐stick blood collected 1 d post‐partum, and from fetuses undergoing evaluation for Rh compatibility. To examine vWF multimers. plasma was separated by electrophoresis on SDS‐agarose gels, overlaid with 125 I‐anti‐vWF, and analysed by densitometry of autoradiographs. Neonatal and fetal plasma contained unusually large von Willebrand factor multimers (ULvWFM), not present in normal adult plasma, in shed blood from adults, in maternal plasma at the time of birth, or in plasma from adults deficient in vitamin K‐dependent coagulation proteins. We conclude that ULvWFM, similar in size to vWF present in the Weibel Paladie bodies of endothelial cells, the alpha granules of platelets, and the plasma of patients with TTP, is present in the fetal circulation, at birth, and shortly after delivery.