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Immunoglobulin light chains in common acute lymphoblastic leukaemia
Author(s) -
Markey Geraldine M.,
Alexander H. D.,
Nolan R. L.,
Morris T. C. M.,
Robertson J. H.
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb06274.x
Subject(s) - immunoglobulin light chain , immunoperoxidase , surface immunoglobulin , antibody , alkaline phosphatase , immunoglobulin heavy chain , immunoglobulin e , immunology , b cell , microbiology and biotechnology , medicine , chemistry , biology , enzyme , monoclonal antibody , biochemistry
Summary A single immunoglobulin light chain λ was identified in the blast cells of two out of 12 patients with common acute lymphoblastic leukaemia (C‐ALL) using the alkaline phosphatase/anti‐alkaline phosphatase (APAAP) technique. Inhibition at the cell surface proved that the reaction was a genuine anti‐λ reaction. Immunoglobulin μ chain was not identified in these patients. Results of immunoglobulin typing in 103 patients with B chronic lymphocytic leukaemia (B‐CLL) are cited to show the increased sensitivity of the APAAP technique as compared to the indirect immunoperoxidase technique for cellular immunoglobulin identification.